Angiopoietin-like protein 3 (Angptl3) mediates hypertriglyceridemia induced by the liver X receptor*
نویسندگان
چکیده
‡The Department of Medicine and Pathophsiology, Graduate School of Frontier Bioscience and Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871; †Pharmacology and Molecular Biology Research Laboratories and ‡‡Biomedical Research Laboratories, Sankyo Co., Ltd. 2-58 Hiromachi 1-tyome, Shinagawa-ku, Tokyo 140-8710; ††Medical Safety Research Laboratories, Sankyo Co., Ltd. 717 Horikoshi, Fukuroi, Shizuoka 437-0065, Japan. #The 21 Century COE Program. **PREST, Japan Science and Technology Corporation (JST).
منابع مشابه
Regulation of the angiopoietin-like protein 3 gene by LXR.
Angiopoietins are members of the vascular endothelial growth factor family. One family member, angiopoietin-like protein 3 (Angptl3), was recently shown to be predominantly expressed in the liver and to play an important role in regulating lipid metabolism. In this study, we show that the Angptl3 gene is a direct target of the liver X receptor (LXR). Mice fed a high cholesterol diet exhibited a...
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